Tissue-level mechanical stimuli drive bone formation and resorption in humans and mice
نویسندگان
چکیده
منابع مشابه
Local Mechanical Stimuli Regulate Bone Formation and Resorption in Mice at the Tissue Level
Bone is able to react to changing mechanical demands by adapting its internal microstructure through bone forming and resorbing cells. This process is called bone modeling and remodeling. It is evident that changes in mechanical demands at the organ level must be interpreted at the tissue level where bone (re)modeling takes place. Although assumed for a long time, the relationship between the l...
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Too often, unique loading environments fail to alter bone mass and morphology, calling to question the validity of Wolff's Law; the skeleton's plasticity to mechanical signals(1). We propose that bone can accommodate new loading environments without the need to form or resorb tissue, and that a critical aspect of bone tissue's ability to adapt to mechanical stimuli is first achieved via the pla...
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15 صفحه اولIn vivo loading increases mechanical properties of scaffold by affecting bone formation and bone resorption rates.
A successful bone tissue engineering strategy entails producing bone-scaffold constructs with adequate mechanical properties. Apart from the mechanical properties of the scaffold itself, the forming bone inside the scaffold also adds to the strength of the construct. In this study, we investigated the role of in vivo cyclic loading on mechanical properties of a bone scaffold. We implanted PLA/β...
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ژورنال
عنوان ژورنال: Bone Reports
سال: 2021
ISSN: 2352-1872
DOI: 10.1016/j.bonr.2021.101032